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In Vivo Pharmacology and Toxicology

With numerous disease models developed in the past 10 years, and the experience built within the pharmaceutical industries, biotech and academia, our highly professional in vivo pharmacology team supports drug discovery projects, fully integrated with other preclinical disciplines.

The core areas of our PD expertise are inflammation, infection, fibrosis and we intend to expand into additional areas in 2021. We apply a comprehensive approach to primary and secondary pharmacodynamic profiling of the compounds to ensure generation of high-quality data relevant to human disease. Our in-depth expertise in translational biomarker selection and validation gives confidence in the smooth transition of the candidate molecule into the clinic.

Individual efficacy studies or tailored in vivo pharmacology packages can also be provided, to cover specific client needs. A full panel of automated clinical biochemistry, haematology and coagulation analyses as well as histopathology and a range of molecular biology techniques are available to support investigation of the compound efficacy.

Our toxicology group supports integrated drug discovery projects by standard and customized studies in rodents.

Our primary objective is to discharge in vivo safety liabilities through tailored study design. We offer you investigative, problem solving studies with fit-for-purpose, integrated assessment of multiple endpoints (general toxicology, pathology and DMPK endpoints).

You can benefit from our broad experience with different targets and mechanisms as it allows us to deal with unexpected findings or toxicity issues during the course of research projects.

In vivo experiments are performed at Fidelta, Selvita Group company, in AAALAC-I accredited State-of-the-Art animal facility (BSL2) with the competent veterinary personnel, technicians and hygiene personnel holding training certificates equivalent to FELASA categories A to D. Animal related research is based on the 3R principles and high-performance standards ensuring animal welfare, humane and ethical use of animals in scientific research.

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